Adrenergic mechanisms

The discovery in 1895 of the hypertensive effect of adrenaline (epinephrine) was initiated by Dr Oliver, a physician in practice, who conducted a series of experiments on his young son into whom he injected an extract of bovine suprarenal. The effect was confirmed in animals and led eventually to the isolation and synthesis of adrenaline in the early 1900s. Many related compounds were examined and, in 1910, Barger and Dale invented the word sympathomimetic1 and also pointed out that noradrenaline (norepinephrine) mimicked the action of the sympathetic nervous system more closely than did adrenaline.

Adrenaline, noradrenaline and dopamine are formed in the body and are used in therapeutics. The natural synthetic path is: tyrosine —> dopa —» dopamine —> noradrenaline —> adrenaline.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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