In the purposeful search that followed the demonstration of the clinical efficacy of penicillin, streptomycin was obtained from Streptomyces griseus in 1944, cultured from a heavily manured field, and also from a chicken's throat. Aminoglycosides resemble each other in their mode of action, and their pharmacokinetic, therapeutic and toxic properties. The main differences in usage reflect variation in their range of antibacterial activity; cross-resistance is variable.
Mode of action. The aminoglycosides act inside the cell by binding to the ribosomes in such a way that incorrect amino acid sequences are entered into
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