Antimetabolites are synthetic analogues of normal metabolites and act by competition, i.e. they 'deceive' or 'defraud' bodily processes.

Methotrexate, for example, a folic acid antagonist, competitively inhibits dihydrofolate reductase, preventing the synthesis of tetrahydrofolic acid (the coenzyme that is important in synthesis of amino and nucleic acids). This drug also provides a cogent illustration of the need to exploit every possible

6 A metabolite, acrolein, of cyclophosphamide and ifosfamide causes haemorrhagic cystitis. A high urine volume plus use of mesna (sodium 2-mercapto-ethanesulphonate) which provides free thiol groups that bind acrolein, are used to prevent this serious complication.

M [mitosis'

Spindle poisons n

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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