Bcg

(Bacilli Calmette-Guêrin) Trastuzumib (Herceptin)

Interferon alfa lnterleukin-2

Isotretinoin

Octreotide Rituximab

Acute toxicity

Bladder irritation; nausea and vomiting; fever; sepsis

Fever: chills: nausea and vomiting; pain; hypersensitivity and pulmonary reactions

Fever; chills; myalgias; fatigue; headache; arthralgias; hypotension

Fever; fluid retention; hypotension; respiratory distress; rash, anaemia, thrombocytopenia; nausea and vomiting: diarrhoea, capillary leak syndrome, nephrotoxicity: myocardial toxicity, hepatotoxicity; erythema nodosum; neutrophil chemotactic defects

Fatigue; headache: nausea and vomiting; pruritis

Nausea and vomiting; diarrhoea

Fever; chills; rigors; hypotension; bronchospasm

Delayed toxicity

Granulomatous pyelonephritis; hepatitis; urethral obstruction; epididymitis; renal abscess Bone marrow depression; cardiomyopathy; ventricular dysfunction; congestive cardiac failure; diarrhoea

Bone marrow depression; anorexia; neutropenia; anaemia; confusion: depression; renal toxicity: hepatic toxicity; facial and peripheral oedema: cardiac arrhythmias

Neuropsychiatrie disorders:hypothyroidism; nephrotic syndrome: possibly acute leucoencephalopathy; brachial plexopathy; bowel perforation

Teratogenic; cheilitis: xerostomia: rash: conjunctivitis and eye irritation; anorexia; hypertriglyceridaemia: pseudotumour cerebri S tea to rr h oea : ga I Is ton es

Bone marrow depression; angioedema; precipitation of angina or arrhythmia with pre-existing heart disease

Carcinogenicity (second malignancies). Many cytotoxic drugs are carcinogenic, and a patient may be cured of the primary disease only to succumb to a second, treatment-induced cancer 5-20 years later. Whether this is due to a mutagenic effect, to immunosuppression, or both, remains undecided. Alkylating agents are particularly incriminated and also some antimetabolites (mercaptopurine) and cytotoxic antibiotics (doxorubicin). The risk can be as high as 10-20 times that of unexposed people and the cancers include leukaemia, lymphoma and squamous carcinoma.

In Hodgkin's lymphoma life is greatly prolonged by chemotherapy, but in ovarian cancer it is not; these aspects are plainly relevant to acceptance of risk of second tumours.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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