Choice Of Oestrogen

Ethinyloestradiol, or its methylated derivative mestranol, is a satisfactory first choice for pharmacotherapy. The weaker endogenous oestrogens, oestradiol, oestrone or the conjugated equine oestrogens are preferable for physiological replacement. It remains uncertain whether all oestrogens have exactly similar hormonal and nonhormonal effects, including adverse effects.

Transdermal formulations of estradiol are available. They can be effective and convenient for women who dislike taking oral therapy. Both oestradiol and oestriol can be taken vaginally as a cream, ring, pessary or tablet.

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