Clinical Pharmacology

'Nature is not only odder than we think, but it is odder than we can think.' J B S Haldane 1893-1964

'Patients may recover in spite of drugs or because of them.' J H Gaddum 1959

'But know also, man has an inborn craving for medicine ... the desire to take medicine is one feature which distinguishes man the animal, from his fellow creatures. It is really one of the most serious difficulties with which we have to contend ... the doctor's visit is not thought to be complete without a prescription.' William Osier 1894

'Morals do not forbid making experiments on one's neighbour or on one's self ... among the experiments that may be tried on man, those that can only harm are forbidden, those that are innocent are permissible, and those that may do good are obligatory.' 'Men who have excessive faith in their theories or ideas are not only ill prepared for making discoveries; they make very poor observations ... they can see in [their] results only a confirmation of their theory ... This is what made us say that we must never make experiments to confirm our ideas, but simply to control them.' 'Empiricism is not the negation of science, as certain physicians seem to think; it is only its first stage.'

'Medicine is destined to get away from empiricism little by little; like all other sciences, it will get away by the scientific method.'

'Considered in itself, the experimental method is nothing but reasoning by whose help we methodically submit our ideas to experience — the experience of facts.' Claude Bernard 1865

'I do not want two diseases — one nature-made, one doctor-made.' Napoleon Bonaparte 1820

"The ingenuity of man has ever been fond of exerting itself to varied forms and combinations of medicines.' William Withering 1785

'All things are poisons and there is nothing that is harmless, the dose alone decides that something is no poison.' Paracelsus 1493-1541

'It is a good remedy sometimes to use nothing.' Hippocrates 460-355 B.C.

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