Coagulation system

The blood coagulation system is shown in simplified form in Figure 28.1. It consists of glycoprotein components that circulate in (necessarily inactive) pro-enzyme or pro-cofactor (factors V and VIII) form. The activated enzymes are serine proteases.

Physiological coagulation (the 'extrinsic' pathway) begins when tissue factor (TF, tissue thromboplastin), exposed by vascular injury, activates and complexes with factor VII to activate factors IX and X which complex with Villa and Va respectively on membrane surfaces (which provide phospholipid, PL). The Xa/Va complex converts prothrombin to thrombin which converts fibrinogen to fibrin and also activates factors XI, VIII, V and XIII, both accelerating coagulation and cross-linking fibrin (-F-F-F-).

The 'intrinsic' pathway refers to coagulation in vitro. It is initiated when factor XII with the cofactor high molecular weight kininogen (HMWK) comes into contact with a foreign surface, e.g. glass, kaolin. Thus it has no physiological role (and patients lacking factor XII do not have a bleeding disorder).

pathway

Foreign surface

Damaged tissue

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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