Dose Adjustment For Patients With Renal Impairment

Adjustment of the initial dose (or where necessary the priming or loading dose, see p. 117) is generally unnecessary, for the volume into which the drug has to distribute should be the same in the uraemic as in the healthy subject.

Adjustment of the maintenance dose involves either reducing each dose given or lengthening the time between doses.

Special caution is needed when the patient is hypoproteinaemic and the drug is usually extensively plasma protein bound, or in advanced renal disease when accumulated metabolic products may compete for protein binding sites; particular care is required in the early stages of dosing until response to the drug can be gauged.

General rules

1. Drugs that are completely or largely excreted by the kidney or drugs that produce active, renally-

TABLE 26.1 Drug tij (h) with normal and with severely impaired renal function

Was this article helpful?

0 0
Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment