Iodide effects are complex and related to dose and to thyroid status of the subject.
In hyperthyroid subjects a moderate excess of iodide may enhance hormone production by providing 'fuel' for hormone synthesis. But a substantial excess inhibits hormone release and promotes storage of hormone and involution of the gland, making it firmer and less vascular so that surgery is easier. The effect is transient and its mechanism uncertain.
In euthyroid subjects with normal glands an excess of iodide from any source can cause goitre (with or without hyperthyroidism), e.g. use of iodide-containing cough medicines, iodine-containing radiocontrast media, amiodarone, seaweed eaters.
A euthyroid subject with an autonomous adenoma (hot nodule) becomes hyperthyroid if given iodide.
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