Aqueous channels in the tight junctions between adjacent epithelial cells allow the passage of some water-soluble substances. Neutral or uncharged, i.e. nonpolar, molecules pass most readily since the pores are electrically charged. Within the alimentary tract, channels are largest and most numerous in jejunal epithelium and filtration allows for rapid

6 Most drugs have a molecular weight of less than 600 (e.g. diazepam 284, morphine 303) but some have more (erythromycin 733, digoxin 780).


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