Hypothalamic and pituitary hormones

Hypothalamus: hormone-releasing hormones, hormone-releasing inhibiting hormones, gonadorelin.

Anterior pituitary: growth hormone, gonadotrophs hormones, corticotropin, thyrotrophin,

Posterior pituitary: vasopressin, oxytocin.

Once the structure of natural hormones, local or systemic (including hormone-releasing hormones), is defined it becomes possible to synthesise not only the hormones themselves1 but also analogues and antagonists. Thus, increasingly, substances become available differing in selectivity and duration of action, and active by various routes of administration.

1 Hormones can be synthesised directly in the chemical laboratory or by inserting mammalian genes into microbes, e.g. Escherichia coli recombinant DNA technology.

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