Indications For Oestrogen Therapy

Replacement therapy in hypoestrogenaemia. This term refers to decreased oestrogen production due to ovarian disease, or to hypothalamic/pituitary disease (hypogonadotropic hypogonadism). Treatment is by cyclic oestrogen (conjugated oestrogens 0.625/1.25 mg daily or ethinylestradiol 20-30 micrograms daily for 21 days) plus a progestogen, medroxyprogesterone 2.5 to 10 mg daily for the last 10 to 14 days of oestrogen treatment. An alternative treatment is the oral contraceptive (see p. 721).

Unless the cause of the hypo-ovarian state is primary ovarian failure, treatment should be stopped after every third cycle to see if spontaneous menstruation will occur.

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