Induction Of Abortion

Gemeprost, administered vaginally as pressaries is the preferred prostaglandin for the medical induction of late therapeutic abortion. Gemeprost ripens and softens the cervix before surgical abortion, particularly in primigravida. Misoprostol by mouth or by vaginal administration or gemeprost may be given to induce medical abortion (an unlicensed indication in the UK). Pretreatment with mifepristone (see p. 720) can facilitate the process, by sensitising the uterus to the prostaglandin so that abortion occurs in a shorter time and with a lower dose of prostaglandin.

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