• Allergic responses are suppressed. The antigen-antibody interaction is unaffected, but its injurious inflammatory consequences do not follow.

• Antibody production is reduced by heavy doses.

• Lymphoid tissue is reduced (including leukaemic lymphocytes).

• Renal excretion of urate is increased.

• Blood eosinophils are reduced in number.

• Euphoria or psychotic states may occur, perhaps due to CNS electrolyte changes.

• Anti-vitamin D action, see calciferol (p. 738).

• Reduction ofhypercalaemia chiefly where this is due to excessive absorption of calcium from the gut (sarcoidosis, vitamin D intoxication).

• Urinary calcium excretion is increased and renal stones may form.

• Growth reduction where new cells are being added (growth in children), but not where they are replacing cells as in adult tissues.

• Suppression of hypothalamic/pituitary/adrenocortical feedback system (with delayed recovery) occurs with chronic use, so that abrupt withdrawal leaves the patient in a state of adrenocortical insufficiency.

Normal daily secretion of hydrocortisone is 10-30 mg. The exogenous daily dose that completely suppresses the cortex is hydrocortisone 40-80 mg, or prednisolone 10-20 mg, or its equivalent of other agents. Recovery of function is quick after a few days' use; but when used over months recovery takes months. A steroid-suppressed adrenal continues to secrete aldosterone.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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