at Table 7.2 will show. These include many lipid-soluble drugs, which may enter fat stores, e.g. most benzodiazepines, verapamil and lignocaine. Less is known about other tissues, e.g. muscle, than about plasma protein binding because solid tissue samples can be obtained only by invasive biopsy, but extensive binding to tissues delays elimination from the body and accounts for the long tV2 of chloroquine and amiodarone. Displacement from tissue binding sites may be a mechanism for pharmacokinetic interaction (see p. 131).

abolition of biological activity but various steps in between may have the following consequences:

1. Conversion of a pharmacologically active to an inactive substance: this applies to most drugs.

2. Conversion of one pharmacologically active to another active substance: this has the effect of prolonging drug action.

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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