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at Table 7.2 will show. These include many lipid-soluble drugs, which may enter fat stores, e.g. most benzodiazepines, verapamil and lignocaine. Less is known about other tissues, e.g. muscle, than about plasma protein binding because solid tissue samples can be obtained only by invasive biopsy, but extensive binding to tissues delays elimination from the body and accounts for the long tV2 of chloroquine and amiodarone. Displacement from tissue binding sites may be a mechanism for pharmacokinetic interaction (see p. 131).

abolition of biological activity but various steps in between may have the following consequences:

1. Conversion of a pharmacologically active to an inactive substance: this applies to most drugs.

2. Conversion of one pharmacologically active to another active substance: this has the effect of prolonging drug action.

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