The distinctive features of allergic reactions are their:10

• Lack of correlation with known pharmacological properties of the drug

• Lack of linear relation with drug dose (very small doses may cause very severe effects)

• Rashes, angioedema, serum sickness syndrome, anaphylaxis or asthma; characteristics of classic protein allergy

• Requirement of an induction period on primary exposure, but not on re-exposure

• Disappearance on cessation of administration and reappearance on re-exposure

• Occurrence in a minority of patients receiving the drug

• Temporary nature in some cases

• Possible response to desensitisation.

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