Fig. 22.1 Cardiovascular effects of noradrenaline (norepinephrine), adrenaline (epinephrine) and isoprenaline (isoproterenol): pulse rate/min, blood pressure in mmHg (dotted line is mean pressure), peripheral resistance in arbitrary units.The differences are due to the differential a and (1 agonist selectivities of these agents (see text). (By permission,after GinsburgJ.Cobbold A F I960 ln:Vane J R et al (eds) Adrenergic mechanism. Churchill, London)

after myocardial infarction may be due to block of P2-receptor-induced hypokalaemia.

Overdose of sympathomimetics is treated according to rational consideration of mode and site of action (see Adrenaline, below).

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