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The presence of a benzene ring, a hydrocarbon chain, a steroid nucleus or halogen (-Br, -CI, -F) groups favours lipid solubility. Water solubility is favoured by the possession of alcoholic (-OH), amide {-CO.NH,} or Car boxy lie (-COOH) groups, and the formation of glucuronide and sulphate conjugates.

It is useful to classify drugs in a physicochemical sense into:

• Those that are variably ionised according to environmental pH (electrolytes) (lipid-soluble or water-soluble)

• Those that are incapable of becoming ionised whatever the environmental pH (un-ionised, nonpolar substances) (lipid-soluble)

• Those that are permanently ionised whatever the environmental pH (ionised, polar substances) (water-soluble).

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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