include: the inhibition of lipoxygenases (diclofenac, indomethacin); superoxide radical production and superoxide scavenging; effects on neutrophil aggregation and adhesion, cytokine production and cartilage metabolism. Nevertheless, their key action of inhibiting prostaglandin formation is reflected in the range of effects, beneficial and adverse, which the members exhibit. NSAIDs may be categorised according to their COX specificity as:

• COX-2 selective compounds, whose selectivity for inhibiting COX-2 is at least 5 times that for COX-1. The group includes rofecoxib, celecoxib, meloxicam, etodolac and nabumetone.

• Non-COX-2 selective compounds, which comprise all other NSAIDs. These drugs inhibit COX-1 as much as, or even more than, COX-2.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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