include: the inhibition of lipoxygenases (diclofenac, indomethacin); superoxide radical production and superoxide scavenging; effects on neutrophil aggregation and adhesion, cytokine production and cartilage metabolism. Nevertheless, their key action of inhibiting prostaglandin formation is reflected in the range of effects, beneficial and adverse, which the members exhibit. NSAIDs may be categorised according to their COX specificity as:
• COX-2 selective compounds, whose selectivity for inhibiting COX-2 is at least 5 times that for COX-1. The group includes rofecoxib, celecoxib, meloxicam, etodolac and nabumetone.
• Non-COX-2 selective compounds, which comprise all other NSAIDs. These drugs inhibit COX-1 as much as, or even more than, COX-2.
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...