Inhibition Of Nucleic Acid Synthesis

Sulphonamides. Usually their names contain 'sulpha' or 'sulfa'. These drugs, and trimethoprim, with which they may be combined, inhibit synthesis of nucleic acid precursors.

Quinolones are structurally related to nalidixic acid; the names of the most recently introduced members of the group end in '-oxacin', e.g. ciprofloxacin. They act by preventing DNA replication.

Azoles all contain an azole ring and the names end in '-azole', e.g. metronidazole. They act by the production of short-lived intermediate compounds which are toxic to DNA of sensitive organisms. Rifampicin inhibits bacterial DNA-dependent RNA polymerase.

Antimicrobials that are restricted to certain specific uses, i.e. tuberculosis, urinary tract infections, are described with the treatment of these conditions in Chapter 13.

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