Interactions Of Cytotoxics With Other Drugs

Many examples of therapeutic interactions (drug combinations) are shown in Table 30.2. Non-therapeutic interactions can be serious. A com bination of cytotoxics causing dangerous degree of immunosuppression represents an adverse pharmacodynamic interaction. There is also a general case for alertness with drugs that inhibit the metabolism or renal excretion of other drugs. Cimetidine, an inhibitor of several P450-mediated oxidation reactions, delays the breakdown and increases the toxicity of 5-fluorouracil, and similarly, the xanthine oxidase inhibitor allopurinol increases toxicity of mercaptopurine and cyclophosphamide. The renal tubular excretion of methotrexate is reduced by competition with NSAIDs, leading to methotrexate toxicity.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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