Interactions Of Cytotoxics With Other Drugs

Many examples of therapeutic interactions (drug combinations) are shown in Table 30.2. Non-therapeutic interactions can be serious. A com bination of cytotoxics causing dangerous degree of immunosuppression represents an adverse pharmacodynamic interaction. There is also a general case for alertness with drugs that inhibit the metabolism or renal excretion of other drugs. Cimetidine, an inhibitor of several P450-mediated oxidation reactions, delays the breakdown and increases the toxicity of 5-fluorouracil, and similarly, the xanthine oxidase inhibitor allopurinol increases toxicity of mercaptopurine and cyclophosphamide. The renal tubular excretion of methotrexate is reduced by competition with NSAIDs, leading to methotrexate toxicity.

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment