Interactions Of Cytotoxics With Other Drugs

Many examples of therapeutic interactions (drug combinations) are shown in Table 30.2. Non-therapeutic interactions can be serious. A com bination of cytotoxics causing dangerous degree of immunosuppression represents an adverse pharmacodynamic interaction. There is also a general case for alertness with drugs that inhibit the metabolism or renal excretion of other drugs. Cimetidine, an inhibitor of several P450-mediated oxidation reactions, delays the breakdown and increases the toxicity of 5-fluorouracil, and similarly, the xanthine oxidase inhibitor allopurinol increases toxicity of mercaptopurine and cyclophosphamide. The renal tubular excretion of methotrexate is reduced by competition with NSAIDs, leading to methotrexate toxicity.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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