Fig. 19.3 Sagittal brain section illustrating dopaminergic pathways. I. Mesolimbic pathway (overactive in psychotic illness according to the dopamine hypothesis of schizophrenia).VTA= ventrotegmental area. 2. Nigrostriatal pathway (involved in motor control, underactive in Parkinson's Disease and associated with extrapyramidal motor symptoms). 3. Tuberoinfundibular pathway (inhibits prolactin release from the hypothalamus).
mesolimbic system (producing antipsychotic effect) rather than the nigrostriatal system (associated with unwanted motor effects). In contrast to classical antipsychotics, risperidone shares with clozapine an ability antagonise a2-adrenoceptors, a property which may have utility in the treatment of schizophrenia and is seen as an area of interest for developing new drugs.
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