Spermatogenesis is reduced by a number of drugs including sulfasalazine and mesalazine
14 By permission from Smithells R W 1983 In: Hawkins D F (ed) Drugs and pregnancy. Churchill Livingstone, Edinburgh.
(reversible), cytotoxic anticancer drugs (reversible and irreversible) and nitrofurantoin. There has been a global decline in sperm concentration and an environmental cause, e.g. chemicals that possess oestrogenic activity, seems likely.
Causation of birth defects due to abnormal sperm remains uncertain.
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