Mode Of Action

Antiepilepsy (anticonvulsant) drugs inhibit the neuronal discharge or its spread, and do so in one or more of three ways:

1. Reducing cell membrane permeability to ions, particularly the voltage-dependent sodium channels which are responsible for the inward current that generates an action potential. Cells that are firing repetitively at high frequency are blocked preferentially, which permits discrimination between epileptic and physiological activity.

2. Enhancing the activity of gamma-aminobutyric acid (GABA) the principal inhibitory transmitter of the brain; the result is increased membrane permeability to chloride ion, which reduces cell excitability

3. Inhibiting excitatory neurotransmitters, e.g. glutamate.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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