Mode Of Action

Antiepilepsy (anticonvulsant) drugs inhibit the neuronal discharge or its spread, and do so in one or more of three ways:

1. Reducing cell membrane permeability to ions, particularly the voltage-dependent sodium channels which are responsible for the inward current that generates an action potential. Cells that are firing repetitively at high frequency are blocked preferentially, which permits discrimination between epileptic and physiological activity.

2. Enhancing the activity of gamma-aminobutyric acid (GABA) the principal inhibitory transmitter of the brain; the result is increased membrane permeability to chloride ion, which reduces cell excitability

3. Inhibiting excitatory neurotransmitters, e.g. glutamate.

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment