Aztreonam 2 h) is the first member of this class of p-lactam antibiotic. It is active against Gramnegative organisms including Pseudomonas aeruginosa, Haemophilus influenzae and Neisseria meningitidis and gonorrhoeae. Aztreonam is used to treat septicaemia and complicated urinary tract infections, Gram-negative lower urinary tract infections and gonorrhoea.

Adverse effects include reactions at the site of infusion, rashes, gastrointestinal upset, hepatitis, thrombocytopenia and neutropenia. It appears to have a remarkably low risk of causing p-lactam allergy, and may be used with caution in some penicillin-allergic patients.

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