The cause of the progressive destruction of upper and lower motor neurons is unknown. The only drug available, riluzole, may act by inhibiting accumulation of the neurotransmitter, glutamate. In 959 patients, riluzole prolonged median survival time from 13 to 16 months, with no effect on motor function.16 It may cause neutropenia.
15 The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group 1995. Neurology 45:1277-1285
16 Lacomblez L et al 1996 Lancet 347: 1425-1431.
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