Myometrium

Gemeprost (prostaglandin Ej analogue) (Cervagem) is used intravaginally to soften the cervix before operative procedures in the first trimester of pregnancy and for abortion, alone and in combination with an antiprogestogen (mifepristone, p. 720).

Carboprost (prostaglandin F2a analogue) is used for postpartum haemorrhage (resistant to ergometrine and oxytocin) for its oxytocin action. It is highly effective. Adverse effects include hypertension, asthma and pulmonary oedema.

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