Parathyroid Hormone

Parathyroid hormone acts chiefly on kidney increasing renal tubular resorption and bone resorption of calcium; it increases calcium absorption from the gut, indirectly, by stimulating the renal synthesis of la-25-dihydroxycholecalciferol (see Vitamin D). It increases the rate of bone remodelling (mineral and collagen) and osteocyte activity with, at high doses, an overall balance in favour of resorption (osteoclast activity) with a rise in plasma calcium con centration (and fall in phosphate); but, at low doses, the balance favours bone formation (osteoblast activity).

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