Pharmacodynamic Changes In Liver Disease

Patients with severe liver disease characteristically show abnormal end-organ response to drugs. For example:

• CNS sensitivity to opioids, sedatives and antiepilepsy drugs is increased.

• The effect of oral anticoagulants is increased because synthesis of coagulation factors is impaired.

• Fluid and electrolyte balance are altered. Sodium retention may be more readily induced by NSAIDs or corticosteroids; ascites and oedema become more resistant to diuretics.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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