Patients with severe liver disease characteristically show abnormal end-organ response to drugs. For example:
• CNS sensitivity to opioids, sedatives and antiepilepsy drugs is increased.
• The effect of oral anticoagulants is increased because synthesis of coagulation factors is impaired.
• Fluid and electrolyte balance are altered. Sodium retention may be more readily induced by NSAIDs or corticosteroids; ascites and oedema become more resistant to diuretics.
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.