The liver has a large metabolic reserve, and it is only when disease becomes decompensated that important changes in drug handling occur. Parenchymal liver disease e.g. chronic viral or alcoholic liver disease, has more impact on hepatic drug-metabolising enzyme activity than primarily cholestatic conditions, e.g. primary biliary cirrhosis, although clearance of drugs eliminated mainly by biliary excretion will be impaired in the latter.
Hepatocellular injury (toxic, infectious) leads to decreased activity of drug-metabolising enzymes, which is reflected in diminished plasma clearance of drugs that are metabolised. There is much variation between patients, and often overlap with healthy subjects.
Was this article helpful?
Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally