Pharmacokinetics see page 713 Preparations Of Oestrogens

The dose varies according to whether replacement of physiological deficiencies is being carried out (replacement therapy) or whether pharmacotherapy is being used.

• Ethinylestradiol (t1/, 13 h) is a synthetic agent of first choice for pharmacological (mainly contraceptive) uses; it is effective by mouth.

• Estradiol and estriol are orally active mixed natural oestrogens.

• Conjugated estrogens (Premarin) are orally active mixed natural oestrogens containing 50-65% oestrone obtained from the urine of pregnant mares.5

• Estropipate (piperazine oestrone sulphate) is an orally active synthetic conjugate.

• Stilboestrol (diethylstilbestrol) is the first synthetic oestrogen: its use is confined to androgen dependent cancers (breast, prostate).

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