In general, NSAIDs are absorbed almost completely from the gastrointestinal tract, tend not to undergo first-pass (presystemic) elimination, are highly bound to plasma albumin and have small volumes of distribution. Their t\ values in plasma tend to group into those that are short (1-5 h) or long (10-60 h). Differences in tl/2 are not necessarily reflected proportionately in duration of effect, for peak and trough drug concentrations at their intended site of action in synovial (joint) fluid at steady-state dosing, are much less than those in plasma. The vast majority of NSAIDs are weakly acidic drugs that localise preferentially in the synovial tissue of inflamed joints (see pH partition hypothesis, p. 97).
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