Pharmacokinetics

In general, NSAIDs are absorbed almost completely from the gastrointestinal tract, tend not to undergo first-pass (presystemic) elimination, are highly bound to plasma albumin and have small volumes of distribution. Their t\ values in plasma tend to group into those that are short (1-5 h) or long (10-60 h). Differences in tl/2 are not necessarily reflected proportionately in duration of effect, for peak and trough drug concentrations at their intended site of action in synovial (joint) fluid at steady-state dosing, are much less than those in plasma. The vast majority of NSAIDs are weakly acidic drugs that localise preferentially in the synovial tissue of inflamed joints (see pH partition hypothesis, p. 97).

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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