Platinum Drugs

This family of drugs (including cisplatin, carbo-platin, oxaliplatin) crosslink DNA similarly to alkylating agents. The parent drug, cisplatin, is associated with a variety of adverse effects, including severe emetogenicity, nephrotoxicity and ototoxicity. Renal damage can be ameliorated by carefully hydrating patients and emetogenicity is now effectively controlled with 5-HT3-receptor (serotonin) antagonists. Although second- (carboplatin) and third- (oxaliplatin) generation platinum agents are now available with improved toxicity profiles, cisplatin remains a highly effective treatment for, in particular, germ cell tumours, when many patients may be cured.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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