Platinum Drugs

This family of drugs (including cisplatin, carbo-platin, oxaliplatin) crosslink DNA similarly to alkylating agents. The parent drug, cisplatin, is associated with a variety of adverse effects, including severe emetogenicity, nephrotoxicity and ototoxicity. Renal damage can be ameliorated by carefully hydrating patients and emetogenicity is now effectively controlled with 5-HT3-receptor (serotonin) antagonists. Although second- (carboplatin) and third- (oxaliplatin) generation platinum agents are now available with improved toxicity profiles, cisplatin remains a highly effective treatment for, in particular, germ cell tumours, when many patients may be cured.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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