Polyene Antibiotics

These act by binding tightly to sterols present in cell

1 Patients with severe illness, meningitis,AIDS or some other causes of immunosuppression should receive amphotericin.

2 Continue treatment for 6-12 months.

3 For patients with AIDS.

This Table is drawn substantially from the Medical Letter on Drugs and Therapeutics (2001, USA).We are grateful to the Chairman of the Editorial Board for permission to publish the material (PNB, MIB).

membranes. The resulting deformity of the membrane allows leakage of intracellular ions and enzymes, causing cell death. Those polyenes that have useful antifungal activity bind selectively to ergosterol, the most important sterol in fungal (but not mammalian) cell walls.

Amphotericin (amphotericin B)

Amphotericin is negligibly absorbed from the gut

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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