Polyene Antibiotics

These act by binding tightly to sterols present in cell

1 Patients with severe illness, meningitis,AIDS or some other causes of immunosuppression should receive amphotericin.

2 Continue treatment for 6-12 months.

3 For patients with AIDS.

This Table is drawn substantially from the Medical Letter on Drugs and Therapeutics (2001, USA).We are grateful to the Chairman of the Editorial Board for permission to publish the material (PNB, MIB).

membranes. The resulting deformity of the membrane allows leakage of intracellular ions and enzymes, causing cell death. Those polyenes that have useful antifungal activity bind selectively to ergosterol, the most important sterol in fungal (but not mammalian) cell walls.

Amphotericin (amphotericin B)

Amphotericin is negligibly absorbed from the gut

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