Polypeptide Antibiotics

Colistin is effective against Gram-negative organisms particularly Pseudomonas aeruginosa. It is sometimes used for bowel decontamination in neutropenic patients and topically is applied to skin, including external ear infections. It is occasionally used syste-mically for severe infections with multiply resistant Gram-negative pathogens such as pseudomonads when no alternative agents are available. Adverse effects of systemic administration include nephrotoxicity, neurological symptoms and neuromuscular blockade.

Polymyxin B is also active against Gram-negative organisms, particularly Pseudomonas aeruginosa. Its principal use now is topical application for skin, eye and external ear infections.

Gramicidin is used in various topical applications as eye- and ear-drops, combined with neomycin and framycetin.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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