Polypeptide Antibiotics

Colistin is effective against Gram-negative organisms particularly Pseudomonas aeruginosa. It is sometimes used for bowel decontamination in neutropenic patients and topically is applied to skin, including external ear infections. It is occasionally used syste-mically for severe infections with multiply resistant Gram-negative pathogens such as pseudomonads when no alternative agents are available. Adverse effects of systemic administration include nephrotoxicity, neurological symptoms and neuromuscular blockade.

Polymyxin B is also active against Gram-negative organisms, particularly Pseudomonas aeruginosa. Its principal use now is topical application for skin, eye and external ear infections.

Gramicidin is used in various topical applications as eye- and ear-drops, combined with neomycin and framycetin.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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