Precautions With Oralagents

Hypoglycaemia is the most common adverse effect with sulphonylureas, but is less common than with insulin therapy. It can be severe, and prolonged (for days), and may be fatal in 10% of cases, especially in the elderly and in patients with heart failure. Erroneous alternate diagnoses such as stroke may be made.

Renal and hepatic disease. A biguanide should not be used in patients with either condition as the risk of lactic acidosis is too great. Sulphonylureas are potentiated in these diseases and a drug with a short (i.e. not glibenclamide) should be used in low dose.

Age adds to the hazard of oral agents.

Other adverse effects are rare but include skin rashes, gastrointestinal upset, minor derangement of haematological and hepatic indices.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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