Hypoglycaemia is the most common adverse effect with sulphonylureas, but is less common than with insulin therapy. It can be severe, and prolonged (for days), and may be fatal in 10% of cases, especially in the elderly and in patients with heart failure. Erroneous alternate diagnoses such as stroke may be made.
Renal and hepatic disease. A biguanide should not be used in patients with either condition as the risk of lactic acidosis is too great. Sulphonylureas are potentiated in these diseases and a drug with a short (i.e. not glibenclamide) should be used in low dose.
Age adds to the hazard of oral agents.
Other adverse effects are rare but include skin rashes, gastrointestinal upset, minor derangement of haematological and hepatic indices.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.