Preparations And Dosage

Synthetic folic acid is taken orally; for therapy 5 mg daily is usually given for 4 months, or indefinitely if the cause of deficiency cannot be removed; 15 mg/day may be needed in malabsorption states though usually 5 mg is adequate. There is no advantage in giving folinic acid instead of folic acid, except in the treatment of the toxic effects of folic acid antagonists such as methotrexate (folinic acid 'rescue', see p. 608).

• For prophylaxis, with iron, in pregnancy, see page 589

• For prophylaxis in haemolytic diseases and in renal dialysis: 5 mg per day or per week depending on need.

Adverse reactions are rare: allergy occurs, and status epilepticus may be precipitated.

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