Defective oxidation. Variation in response to some drugs can be attributed to genetic polymorphisms involving oxidation of their carbon centres (see Metabolism p. 112). The condition was recognised by abnormal metabolism and response to a standard dose of debrisoquine.28 Individuals may be classed as extensive or poor oxidisers and the latter are at special risk of adverse effects from drugs whose inactivation is strongly dependent on the defective
INHERITED INFLUENCES; PHARMACOGENETICS
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...