Strength Of Evidence

A number of types of clinical investigation are described in this chapter, and elsewhere in the book. When making clinical decisions about a course of therapeutic action, it is obviously relevant to judge the strength of evidence generated by different types of study. This has been summarised as follows, in rank order.38

1. Systematic reviews and meta-analysis

2. Randomised controlled trials with definitive results (confidence intervals that do not overlap the threshold of the clinically significant effect)

3. Randomised controlled trials with nondefinitive results (a difference that suggests a clinically significant effect but with confidence intervals overlapping the threshold of this effect)

4. Cohort studies

5. Case-control studies

6. Cross-sectional surveys

7. Case reports.


Fig. 4.4 Oscillations in the development of a drug.41

38 Guyatt G H et al 1995 Journal of the American Medical Association 274:1800.

Was this article helpful?

0 0
Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

Get My Free Ebook

Post a comment