Hypertension and coronary heart disease (CHD) are of great importance. Hypertension affects above 20% of the total population of the USA with its major impact on those over age 50. CHD is the cause of death in 30% of males and 22% of females in England and Wales. Management requires attention to detail, both clinical and pharmacological.

The way drugs act in these diseases is outlined and the drugs are described according to class.

• Hypertension and angina pectoris: how drugs act

• Drugs used in both hypertension and angina

Diuretics Vasodilators organic nitrates, calcium channel blockers,ACE inhibitors, angiotensin II-receptor antagonists Adrenoceptor blocking drugs, a and p Peripheral sympathetic nerve terminal Autonomic ganglion-blocking drugs Central nervous system Treatment of angina pectoris

Acute coronary syndromes and myocardial infarction

Arterial hypertension

Sexual function and cardiovascular drugs

• Phaeochromocytoma

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