Topical Nsaids

Several NSAIDs have topical preparations, for example ibuprofen (Ibugel), diclofenac (Voltarol emulgel), piroxicam (Feldene gel) and ketoprofen (Oruvail gel). The objective is to produce therapeutic local concentrations without (undesirable) systemic effects. These should not be used on broken or inflamed skin, or on mucous membranes, and may cause photosensitivity and local skin reactions. Although systemic absorption is less than with oral preparations, there are reports of gastrointestinal and also renal toxicity associated with their use. NSAIDs are also available as suppositories, which some patients prefer. Both local and systemic side effects may occur.

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