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1 2 3 4 5 Fructose-2,6-bisphosphate, ||M

FIGURE 23.12 • Inhibition of fructose-1,6-bisphosphatase by fructose-2,6-bisphosphate in the (a) absence and (b) presence of 25 ¡M AMP. In (a) and (b), enzyme activity is plotted against substrate (fructose-1,6-bisphosphate) concentration. Concentrations of fructose-2,6-bisphosphate (in ¡M) are indicated above each curve. (c) The effect of AMP (0, 10, and 25 ¡M) on the inhibition of fructose-1,6-bisphosphatase by fructose-2,6-bisphos-phate. Activity was measured in the presence of 10 ¡M fructose-1,6-bisphosphate. (Adapted from Van Schaftingen, E, and Hers, H.-G, 1981. Inhibition of fructose-1,6-bisphosphatase by fructose-2,6-bis-phosphate. Proceedings of the National Academy of Science, USA 78:2861—2863.)

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