supplies.) Second, the term high-energy compound should not be construed to imply that these molecules are unstable and hydrolyze or decompose unpredictably. ATP, for example, is quite a stable molecule. A substantial activation energy must be delivered to ATP to hydrolyze the terminal, or y, phosphate group. In fact, as shown in Figure 3.8, the activation energy that must be absorbed by the molecule to break the O—Py bond is normally 200 to 400 kJ/mol, which is substantially larger than the net 30.5 kJ/mol released in the hydrolysis reaction. Biochemists are much more concerned with the net release of 30.5 kJ/mol

Compound (and Hydrolysis Product)


Lower-Energy Phosphate Compounds


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