Side Effects Toxicity and Contraindications of the Macrolide Antibiotics

The majority of side effects associated with macrolide antibiotics are mild and transient in nature. The most frequently reported events in adults are diarrhea, nausea, abnormal taste, dyspepsia, abdominal pain (substantially less with newer macrolides), and headache. Like other kinds of antibiotics, pseudomembranous colitis has been reported with macrolide use, ranging in severity from mild to life-threatening. There have been isolated reports of transient central nervous system side effects...