Biological Activity and Side Effects

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Both 5-fluorouracil and cytosine arabinoside remain widely used in combination cancer chemotherapy. 5-Fluorouracil is one of the most effective drugs against colon cancer (311).Cytosine arabinoside is effective in leu-kemias and lymphomas but has a very short half-life (ca. 12 min in man), because of catab-olism by cytidine deaminase (321), and various non-specific prodrug forms are used (322). Gemcitabine was shown in phase I trials to be active in a number of cancers, especially in non-small-cell lung cancer, where it showed >20% responses as a single agent and up to 54% in combination with cisplatin (323). In phase II trials, it has proved active in a wide range of tumors, including non-small-cell lung cancer (>60% responses in combination with cisplatin) (324), urothelial (22-28% responses as monotherapy, 42-66% in combination with cisplatin) (325), advanced breast cancer (25.0%responses as monotherapy) (326), and metastatic bladder cancer 42-66% responses in combination with cisplatin) (327).The main adverse effects were hematological but were generally mild. A number of large phase III trials are in progress.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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