kidney, skin, intestines) except lung

SSA, Sjögren syndrome A; SSB, Sjörgen syndrome B.

SSA, Sjögren syndrome A; SSB, Sjörgen syndrome B.

Autoimmunity can damage nearly every tissue or cell type of the body. The spectrum, severity, and duration of disease vary widely. Depending on the organ systems involved, systemic and organ-specific autoimmune diseases have been delineated. Systemic autoimmune diseases include SLE, RA, scleroderma, Wegener's granulomatosis, Goodpasture syndrome, Sjogren's syndrome, der-matomyositis, psoriasis, ankylosing spondylitis, and inflammatory bowel diseases (Table 2).

Although SLE can involve almost any tissue of the body, inflammatory bowel diseases extend to fewer tissues, the gut, the joints, and the eye. Organ-specific diseases include insulin-dependent diabetes mellitus (IDDM), multiple sclerosis (MS), uveitis, thyroiditis, pernicious anemia, autoimmune hemolytic anemia, thrombocytopenia, hepatitis, primary biliary cirrhosis, pemphigus, pemphigoid, and vitiligo (Table 3). Individual patients may have more than one autoimmune disorder concurrently and subsequently.

Table 3

Organ-Specific Autoimmune Diseases

Table 3

Organ-Specific Autoimmune Diseases


Typical involvement and immunopathology


Pancreas; antiinsulin and anti-glutamic acid decarboxylase

diabetes mellitus


Multiple sclerosis

Central nervous system; antimyelin T-cell and antibody

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