Monoclonal Gammopathies

In this situation, a monoclonal protein is present in serum M protein . This is an immunoglobulin which persists constantly at an elevated level over many years without the development of any malignant systemic disease. It is caused by the proliferation of a single clone of mature differentiated B lymphocytes producing this y-globulin. This monoclonal immunoglobulin may not only be directed against proteins of the coagulation pathway usually factor VIII but may also be an antibody against the...