As the "guardian of the genome", p53 is the main regulator preventing carcinogenic and teratogenic lesions [24, 25]. Therefore, it is not surprising that the loss of p53 function(s) is linked to the development of human cancer. Mutations of this tumor suppressor gene are the most frequently reported gene alteration in human cancers [26, 27]. In 1982, it was shown for the first time that p53 may become immunogenic in cancer pa-
Table 3. Autoantibody response against p53 in different groups of former uranium miners
Group of uranium miners or control subjects
p53 antibody response (in%)
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