Conclusion

In conclusion, the physiological role of the CD5+ B cells in normal individuals representing a putative separate B cell lineage are likely, through a framework of self-reactivities, to be involved in establishing the immune system repertoire. This cell subset appears to be a target lymphocyte population, the aberrant function of which is associated with nonorgan-specific autoimmune diseases and B lymphoproliferative disorders. Studies on the regulation of CD5+ B-cell production and function are likely to shed light on the etiology, and pathogenetic pathways operating in these distinctive disease states.

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