Hypoglycemia Syndromes

The most common neoplasms associated with hypoglycemia are tumors of "mesenchymal" origin, such as mesotheliomas, fibrosarcomas, neurofibromas, spindle cell carcinomas and leiomyosarcomas. The most common mechanism involved in hypoglycemia is abnormal production of a precursor molecule to insulinlike growth factor (IGF) II, which is bound to insulin and IGF receptors, thus causing suppression of growth hormone secretion [8].

Other rare causes that are not well documented are the production of insulin in excessive quantities and increased insulin receptor numbers in the liver and muscles.

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